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The gender bender took a shot of whiskey before accepting the award from the cast of the 'Jersey Shore' and seasoned comedian Cloris Leachman.
"It doesn't matter who you are -- gay, straight, lesbian, bi, transgendered -- you were born this way," "not-Gaga" asserted in her raspy, deeper-than-usual smoker's voice.
Mother Monster beat out Adele, Beyonce, Katy Perry and Nicki Minaj for the coveted Best Female Video moonman.
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Watch Lady Gaga Perform 'You and I' at the 2011 VMAs